Pharmacological Effects: Antiemetic, is a specific blocker of dopamine (D2) and serotonin receptor. Eliminates nausea and hiccups. Reduces motor activity of the esophagus increases the lower esophageal sphincter tone, accelerates gastric emptying, and accelerates the progress of food through the small intestine without causing diarrhea. Stimulates the secretion of prolactin.
Indications: Vomiting, nausea, hiccups of various origins (in some cases it may be effective for vomiting caused by radiation or chemotherapy), and hypotension atony of the stomach and intestines (particularly postoperative) biliary dyskinesia, reflux esophagitis, flatulence, worsening of gastric ulcer and 12 duodenal ulcer (in the complex therapy). Radiopaque study the gastrointestinal tract (to enhance peristalsis).
Contraindications: Hypersensitivity, gastrointestinal bleeding, pyloric stenosis of the stomach, mechanical intestinal obstruction, perforation of the stomach or intestine, pheochromocytoma, extrapyramidal disorders, epilepsy, prolaktinozavisimye tumor, pregnancy, laktatsii.C caution. Bronchial asthma, hypertension, Parkinson's disease, hepatic and / or renal failure, advanced age, early childhood (increased risk of diskineticheskih syndrome).
Side effects: Constipation or diarrhea, dry mouth, fatigue, drowsiness, headache, dizziness, depression. Chronic administration of the drug in high doses, more frequently in elderly patients, the phenomenon of parkinsonism, dyskinesia, galactorrhea, gynecomastia, menstrual irregularities tsikla.Peredozirovka. Symptoms: hypersomnia, disorientation, and extrapyramidal disorder. Symptoms disappear after stopping treatment within 24 hours
Dosage and administration: Solution for injection is administered IV or IM in adults 10-20 mg (maximum daily dose - 60 mg) for children older than 6 years - 5 mg 1-3 times a day for children aged 6 years daily dose is 0.5-1 mg / kg, the multiplicity of reception - 1-3 times. To prevent and treat nausea and vomiting caused by cytotoxic drugs or receiving radiation therapy, the drug is administered iv at a dose of 2 mg / kg 30 min before application of cytotoxic drugs or radiation, if necessary, the introduction is repeated in 2-3 hours inside. Adults - 5-10 mg 3-4 times a day for 30 minutes before a meal, swallow a pill whole and washed down with sips of water. The maximum single dose is 20 mg daily - 60 mg. Children over 6 years are designated by 5 mg 1-3 times a day.
Special instructions: During the period of drug treatment is not recommended to use ethanol. During the period of treatment must be careful when driving vehicles and occupation of other potentially hazardous activities that require high concentration of attention and quickness of psychomotor reactions.
Interaction: The action could weaken the anticholinesterase drugs. The drug increases the absorption of tetracycline, ampicillin, acetaminophen, ASA, levodopa, ethanol reduces the absorption of digoxin and cimetidine. The drug is not prescribed in conjunction with antipsychotic drugs (increased risk of extrapyramidal disorders). You can buy Maxolon in medstore.biz Generic drugs |